Uncommon Instances of COVID Relapse Seen With Pfizer Tablet

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News Picture: Rare Cases of COVID Relapse Seen With Pfizer Pill

TUESDAY, Might 10, 2022

Uncommon circumstances of COVID sufferers relapsing after taking the antiviral capsule Paxlovid are elevating questions amongst some consultants.

An earlier research of 1,000 adults confirmed that Paxlovid was highly effective at stopping extreme COVID and the U.S. authorities has purchased sufficient of the drug to deal with 20 million folks.

However there have been stories of signs returning in sufferers a number of days after finishing the five-day routine of Paxlovid, prompting some docs to surprise if these sufferers are nonetheless contagious and may take a second spherical of the drug.

However the U.S. Meals and Drug Administration final week advised towards a second spherical, saying there may be little danger of extreme sickness or hospitalization amongst sufferers who relapse after taking Paxlovid.

The Pfizer drug was examined and licensed based mostly on its effectiveness towards the Delta variant and could also be much less efficient towards Omicron, famous Dr. Michael Charness, who works for Boston’s VA well being system.

He handled a 71-year-old vaccinated affected person whose signs eased however then returned, together with a surge in virus ranges, 9 days into his bout of COVID-19.

“The power to clear the virus after it is suppressed could also be totally different from Omicron to Delta, particularly for vaccinated folks,” Charness informed the Related Press.

Within the unique research, virus ranges rose after 10 days in 1% to 2% in these taking both the drug or dummy capsules, Pfizer and the FDA have famous, the AP reported. That fee was about the identical amongst folks taking the drug or dummy capsules, “so it’s unclear at this level that that is associated to drug therapy,” the FDA said, the AP mentioned.

One other potential rationalization for uncommon circumstances of relapse amongst sufferers taking Paxlovid is that the dose is not sturdy sufficient to totally suppress the virus in all folks, mentioned Andy Pekosz, a virologist at Johns Hopkins College in Baltimore. That would result in coronavirus mutations which are immune to the remedy, he mentioned.

“We must always actually be certain we’re dosing Paxlovid appropriately as a result of I might hate to lose it proper now,” Pekosz informed the AP. “This is without doubt one of the important instruments we now have to assist us flip the nook on the pandemic.”

Extra info

Go to the Yale College of Medication for extra on Paxlovid.

SOURCE: Related Press

By Robert Preidt and Robin Foster HealthDay Reporters

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