People on Immune-Suppressing Meds Fare Equally Well With Severe COVID

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News Picture: People on Immune-Suppressing Meds Fare Equally Well With Severe COVID

MONDAY, Nov. 22, 2021 (HealthDay Information)

Hospitalized COVID-19 sufferers who take drugs that suppress the immune system do not have the next danger of extreme COVID-19 than these with regular immune methods, a brand new research finds.

Early within the pandemic, it was feared that folks taking immunosuppressive drugs had been at elevated danger of extreme COVID-19 on account of their weakened immune methods. The drugs are used to deal with cancer and autoimmune ailments, and to stop transplant rejection, for example.

“Basically, folks taking immunosuppressive drugs could also be reassured that they’ll safely proceed to take action throughout this pandemic,” stated lead creator Kayte Andersen, a doctoral candidate at Johns Hopkins Bloomberg Faculty of Public Well being, in Baltimore.

To study extra, her crew analyzed information from almost 222,600 U.S. adults hospitalized with COVID-19 from January 2020 to June 2021. Of these, 7% had been taking immunosuppressive medication earlier than hospitalization.

The investigators separated the immunosuppressive drugs into 17 courses and located that none was related to a considerably greater danger of being placed on a ventilator, a sign of extreme COVID-19 sickness.

The findings had been revealed on-line Nov. 15 in The Lancet Rheumatology journal.

“These findings are encouraging and essential, given how generally these drugs are used,” stated research co-author G. Caleb Alexander, a professor of epidemiology at Johns Hopkins.

The researchers did hyperlink one drug, rituximab, with a considerably elevated danger of loss of life. The drug is given to sufferers with critical medical situations like cancer or an autoimmune dysfunction that has not responded to different remedies.

“Given the discovering, sufferers taking rituximab ought to focus on their choices with their physician,” Andersen stated in a Hopkins information launch. “At a minimal, individuals who take rituximab ought to proceed to guard themselves from creating COVID-19. It additionally makes it all of the extra essential that folks round these taking rituximab get vaccinated.”

The researchers additionally discovered {that a} comparatively new class of immunosuppressive medication known as JAK inhibitors — used to deal with arthritis, inflammatory bowel disease and different inflammatory situations — had been related to a 58% decrease danger of COVID-related in-hospital loss of life.

JAK inhibitors akin to baricitinib have just lately been used to deal with extreme COVID-19, the researchers famous.

Extra info

The U.S. Nationwide Cancer Institute has extra on immunotherapy for cancer.

SOURCE: Johns Hopkins Bloomberg Faculty of Public Well being, information launch, Nov. 16, 2021

Robert Preidt

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