New Clues to Why Some Develop ‘Brain Fog’ After COVID

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News Picture: New Clues to Why Some Develop 'Brain Fog' After COVID

THURSDAY, Jan. 20, 2022 (HealthDay Information)

Brain fog. It has grow to be an inexplicable aspect impact of COVID-19 an infection, however researchers now report they’ve found a potential purpose why it occurs.

In a small examine, investigators discovered abnormalities within the cerebrospinal fluid of some COVID-19 sufferers who developed considering issues.

The signs “manifest as issues remembering current occasions, developing with names or phrases, staying centered, and points with holding onto and manipulating info, in addition to slowed processing pace,” defined examine senior writer Dr. Joanna Hellmuth, from the Reminiscence and Aging Middle on the College of California, San Francisco.

Brain fog is a standard aftereffect of COVID an infection, putting about 67% of 156 sufferers at a post-COVID clinic in New York, a current examine discovered.

On this newest examine, the researchers analyzed the cerebrospinal fluid of 13 individuals who had considering and reminiscence issues after COVID-19 and of 4 recovered COVID-19 sufferers with no cognitive signs.

The common age of these with cognitive signs was 48, in contrast with 39 for these with no cognitive signs. The cerebrospinal fluid samples have been collected a median of 10 months after the sufferers’ first COVID-19 signs. Not one of the sufferers have been hospitalized for COVID-19.

Cerebrospinal fluid anomalies have been present in 10 of the 13 sufferers with cognitive signs, however not in any of the 4 with no cognitive signs, in accordance with the examine printed Jan. 19 within the journal Annals of Clinical and Translational Neurology.

The cerebrospinal fluid of sufferers with cognitive signs had elevated ranges of protein, suggesting irritation, in addition to sudden antibodies present in an activated immune system.

A few of these antibodies have been present in each cerebrospinal fluid and blood, indicating a systemic inflammatory response, or have been discovered solely in cerebrospinal fluid, suggesting mind irritation.

Whereas the targets of those antibodies are unknown, they may very well be “turncoat” antibodies that assault the physique itself, in accordance with the researchers.

“It is potential that the immune system, stimulated by the virus, could also be functioning in an unintended pathological approach,” mentioned Hellmuth, who’s principal investigator of the UCSF Coronavirus Neurocognitive Research and can also be affiliated with the UCSF Weill Institute for Neurosciences.

“This could be the case although the people didn’t have the virus of their our bodies,” she mentioned in a college information launch.

The examine additionally discovered that individuals with considering issues had a median of two.5 danger components for impaired considering, in contrast with a median of lower than one danger issue for individuals with out the signs.

These danger components included: diabetes and high blood pressure, which might enhance the danger of stroke, gentle cognitive impairment and vascular dementia; a historical past of attention deficit hyperactivity disorder (ADHD), which can make the mind extra susceptible to govt functioning points; anxiety; depression; a historical past of heavy alcohol or repeated stimulant use; and learning disabilities.

Extra info

For extra on COVID-19 brain fog, go to Harvard Medical School.

SOURCE: College of California, San Francisco, information launch, Jan. 18, 2022

Robert Preidt

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