Might Weight problems Blunt the Response to the COVID Vaccine?

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News Picture: Could Obesity Blunt the Response to the COVID Vaccine?

FRIDAY, Could 6, 2022 (HealthDay Information)

Obesity can complicate the course of COVID-19. Now, a brand new research says it may possibly additionally cut back the effectiveness of COVID vaccines.

The researchers additionally discovered that the 2 vaccines used of their research triggered totally different ranges of immune responses in severely obese individuals. They discovered, too, that prior an infection had an impression.

“These outcomes present new data on the antibody response to SARS-CoV-2 vaccines in individuals with extreme obesity and reinforce the significance of prioritizing and growing vaccine uptake on this susceptible group,” research co-author Volkan Demirhan Yumuk stated in a information launch from the European Congress on Weight problems. Yumuk is a professor at Istanbul College in Turkey.

The research included 124 severely obese adults (common age 42 to 63) and 166 regular weight adults (common age 39 to 47) in Turkey. The obese group had a physique mass index (BMI) — a measure primarily based on peak and weight — of greater than 40.

The individuals obtained two doses of both the Pfizer/BioNTech vaccine or the CoronaVac vaccine made by the Chinese language firm Sinovac.

4 weeks after their second dose, blood samples have been collected from the individuals to measure their ranges of antibodies towards the coronavirus. As well as, their an infection historical past was checked, and 70 have been discovered to have beforehand been contaminated with COVID-19.

Amongst individuals who had no earlier an infection and obtained the Pfizer/BioNTech vaccine, antibody ranges amongst those that have been severely overweight have been greater than thrice decrease than these with regular weight, the research revealed.

Amongst those that had no earlier an infection and obtained the CoronaVac vaccine, antibody ranges among the many severely overweight have been 27 instances decrease than these with regular weight.

Amongst those that’d beforehand been contaminated and obtained both Pfizer/BioNTech or CoronaVac, antibody ranges have been related in each severely overweight and regular weight individuals, in line with the research. The findings have been to be offered at this week’s European Congress on Weight problems in Maastricht, the Netherlands.

The findings have implications for america, the place more than four in 10 people are obese, in line with the U.S. Facilities for Illness Management and Prevention. Greater than 9% are severely overweight.

“Our research confirms that immune reminiscence induced by prior an infection alters the way in which through which individuals reply to vaccination and signifies that two doses of Pfizer/BioNTech vaccine could generate considerably extra antibodies than CoronaVac in individuals with extreme weight problems, no matter an infection historical past,” Yumuk stated.

Nonetheless, Yumuk added, “additional analysis is required to find out whether or not these greater antibody ranges present better safety towards COVID-19.”

Information and conclusions offered at conferences must be thought-about preliminary till printed in a peer-reviewed medical journal.

Extra data

For extra on COVID-19 vaccines, see the U.S. Centers for Disease Control and Prevention.

SOURCE: European Congress on Weight problems, information launch, Could 5, 2022

By Robert Preidt HealthDay Reporter

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