Animal Study Offers Hope for a Vaccine Against Lyme Disease

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News Picture: Animal Study Offers Hope for a Vaccine Against Lyme Disease

TUESDAY, Nov. 23, 2021 (HealthDay Information)

An experimental Lyme disease vaccine exhibits promise in animal research and will additionally assist shield in opposition to different tick-borne illnesses, researchers say.

The vaccine — which depends on the identical mRNA expertise utilized by some COVID-19 vaccines — protected guinea pigs in opposition to an infection by Borrelia burgdorferi, the bacterium that causes Lyme disease.

The vaccine would not set off the immune system to assault B. burgdorferi. As a substitute, it prompts a fast response within the pores and skin to sure proteins in tick saliva, which reduces the period of time a tick has to contaminate the host, the Yale College staff defined.

“The vaccine enhances the power to acknowledge a tick bite, partially turning a tick bite right into a mosquito chew,” stated senior creator Dr. Erol Fikrig, a professor of medication and epidemiology at Yale, in New Haven, Conn.

“While you really feel a mosquito chew, you swat it,” he defined. “With the vaccine, there’s redness and sure an itch so you’ll be able to acknowledge that you’ve been bitten and may pull the tick off shortly, earlier than it has the power to transmit B. burgdorferi.”

In comparison with unvaccinated guinea pigs, people who had been vaccinated shortly developed redness at a tick bite website. So long as ticks had been eliminated when redness appeared, not one of the vaccinated guinea pigs had been contaminated. About half of the unvaccinated guinea pigs grew to become contaminated after ticks had been eliminated, the findings confirmed.

When a single contaminated tick was hooked up to vaccinated guinea pigs and never eliminated, none was contaminated, in contrast with 60% of unvaccinated guinea pigs. But when three ticks remained hooked up to vaccinated guinea pigs, their safety wasn’t as sturdy, in keeping with the report printed Nov. 17 within the journal Science Translational Medication.

The researchers additionally discovered that ticks hooked up to vaccinated guinea pigs had been unable to feed aggressively and dislodged extra shortly than these on unvaccinated guinea pigs.

No less than 40,000 instances of Lyme disease are reported every year in the US, however the precise numbers of infections might be 10 occasions higher, the researchers famous. Different tick-borne illnesses have additionally unfold in lots of areas of the US, they added.

“There are a number of tick-borne illnesses, and this method doubtlessly gives extra broad-based safety than a vaccine that targets a particular pathogen,” Fikrig stated in a college information launch.

“It is also used at the side of extra conventional, pathogen-based vaccines to extend their efficacy,” he added.

Extra analysis is required to find ways in which proteins in saliva can stop an infection, Fikrig stated, and human clinical trials can be wanted to evaluate the vaccine’s effectiveness in folks.

Extra info

The American Academy of Household Physicians has extra on Lyme disease.

SOURCE: Yale College, information launch, Nov. 17, 2021

Robert Preidt

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